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Products to get disqualified from the Olympics: What You Should Know About WADA Rules

Products to get disqualified from the Olympics: What You Should Know About WADA Rules

WADA Regulations

WADA stands as an international, independent agency focused on combating doping in sports. It promotes and coordinates global efforts and also ensures uniform anti-doping standards worldwide. This empowers anti-doping organisations to craft athlete-centric programs, safeguarding fair play across all sports.

WADA maintains a list of prohibited substances and methods in sports. Athletes found using these substances face detection through testing and subsequent disqualification from competitions. This is relevant for all athletes participating in competitive sports governed by anti-doping regulations, ensuring fairness and integrity in various international and national competitions. However, not all performance enhancers are banned by WADA. In this article, we will review some of the stimulants that might be used to boost your sports results.

Not WADA-Approved Athletic Supplements

Mildronate

Mildronate or Meldonium is designed as a protective agent. It operates by mimicking a specific amino acid and has historically been employed in treating heart and brain conditions associated with restricted blood flow. Preliminary research shows that it works by reducing levels of L-carnitine, thereby optimising cellular fat processing and preventing the buildup of harmful byproducts that can damage cell structures. Additionally, Meldonium enhances the oxygen-carrying capacity of red blood cells and modifies cellular energy metabolism
Metabolism — Metabolism is the set of chemical processes that convert food into energy and building blocks for the body. Go to Glossary
to improve glucose utilization. More information is available in the Meldonium overview.

Since January 1, 2016, Meldonium has been designated a banned substance by WADA due to its documented use among athletes. This classification followed high-profile cases such as Maria Sharapova's, where she admitted to using Mildronate and subsequently faced suspension from competition.

Despite accusations of doping, Professor Kalvins, the compound creator, has maintained that Meldonium was developed solely to protect athletes' cardiovascular systems under strenuous physical conditions, emphasising its intended use for cardioprotection rather than performance enhancement beyond normal limits.

Phenylpiracetam

Phenylpiracetam is a derivative of piracetam, and it is marketed in some parts of the world as a compound that is designed to enhance brain function through increased synaptic transmission and wakefulness. Preclinical and limited clinical studies from Eastern Europe suggest neurometabolic and stimulant-like effects, promoting protein and phospholipid synthesis and facilitating the circulation of information molecules in the brain. More information is available in the Phenylpiracetam review.

The nootropic actions of phenylpiracetam include anti-amnesic effects, enhanced cognitive function, improved memory consolidation, and increased inter-hemispheric information transfer. It elevates brain levels of noradrenaline, dopamine
Dopamine — A neurotransmitter in the brain that contributes to alertness, focus, motivation, and feeling of happiness. Go to Glossary
, and serotonin
Serotonin — Neurotransmitter regulating mood, sleep, and appetite. Go to Glossary
without affecting GABA levels or binding to GABA receptors. Limited data found that phenylpiracetam also shows neuroprotective properties, acts as an anticonvulsant and anxiolytic, and can enhance metabolic and redox processes by utilising glucose for enhanced energy.

Physiologically, phenylpiracetam enhances motor reactions and physical performance, improves vision acuity, and promotes blood flow to the extremities. In some animal studies, it exhibits adaptogenic effects, increasing stress resistance during physical and mental exertion, and enhances immune response without inducing hypersensitivity reactions.

Since it is deemed beneficial for athletic performance through the improvement of oxygen tolerance and the reduction of fatigue (although not well quantified in modern controlled trials), phenylpiracetam is listed as a stimulant by WADA. So, athletes are cautioned against its use before competitions due to its stimulating effects and relatively short half-life of 3-5 hours.

Actovegin

Actovegin is a widely used antihypoxic nootropic derived from deproteinized calf blood via ultrafiltration, deemed to enhance cellular oxygen supply and energy metabolism. Comprising over 200 components like amino acids, peptides
Peptides — A family of substances whose molecules are built from two or more amino acids. Peptides encompass around half of all known hormones and the majority of enzymes
Enzymes — Proteins that help speed up chemical reactions in different parts of the body. Go to Glossary
.
Go to Glossary
, nucleosides, and enzymes, Actovegin's pharmacokinetics remain unclear due to its complex composition, mirroring substances found in the human body. More information is available in Actovegin review.

Actovegin is used in some parts of the world in cases of brain vascular and metabolic disorders, circulatory issues, trophic ulcers, burns, wounds, and fetal growth disorders. Considered an ergogenic aid, Actovegin has been marketed and used by athletes, including bodybuilders, aiming to enhance physical performance by boosting cellular metabolism, reducing lactic acid buildup, improving muscle contractility, increasing energy reserves, and enhancing oxygen and glucose transport.

Actovegin sparked controversy when athletes used it during the Sydney Olympics and Tour de France in 2000, prompting speculation about its potential doping effects. However, currently, WADA has not classified Actovegin as a prohibited substance due to a lack of proven efficiency.

Bemiton

Bemiton or Bemitil is a Soviet‑era pharmaceutical known for its adaptogenic and immunostimulant properties. It is researched for its potential to enhance physical and mental performance by improving endurance, reducing fatigue, and bolstering resistance to stress in animal studies.

While it is not explicitly prohibited by WADA, it is still on WADA’s monitoring program. Hence, athletes should exercise caution, as its use may still come under scrutiny if suspected of providing unfair performance advantages.

Conclusion

There are numerous substances available for enhancing athletic performance, some of which are prohibited by WADA, while others are not. It is crucial to handle them with caution, seek guidance from a specialist, and ensure compliance with anti-doping regulations. Athletes must prioritise their health and safety by making informed decisions about the substances they use, understanding the potential risks and benefits under professional supervision. This approach helps maintain integrity in sports and promotes fair competition while safeguarding against health risks associated with the misuse of performance-enhancing substances.

References

1) E Stojanović et al. (2024). The Physiological and Performance Effects of Actovegin during Maximal Cardiopulmonary Exercise Testing: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients

2) TA Voronina (2023). https://www.kp.ru/daily/26502.4/3371477/. Neurochemical Journal

3) D Wang et al. (2022). Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. PubMed

4) P Fleur et al. (2022). Actovegin in the management of patients after ischemic stroke: A systematic review. PubMed

5) L Zvejniece et al. (2020). Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice. PubMed

6) D Kwiatkowska et al. (2018). Detection of bemitil and its metabolite in urine by means of LC-MS/MS in view of doping control analysis. PubMed

7) V Liepins et al. (2017). S-phenylpiracetam, a selective DAT inhibitor, reduces body weight gain without influencing locomotor activity. PubMed

8) E Liepinsh et al. (2016). Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. PubMed

9) MA Samotrueva et al. (2011). [Phenotropyl succinate as the means for correction of neuroimmune disturbances under conditions of informational-physical stress]. PubMed

10) N Herz (2010). FIS, WADA Tight-Lipped on Pankratov; Actovegin’s Benefits Unproven

11) LL Pragina et al. (1999). The effect of bemitil on conditioned-reflex memory in normal rats and under stress exposures. PubMed

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Content is for informational purposes only and is not medical advice. Statements are not evaluated by the FDA or EMA. Always consult your healthcare provider.